vitamins
vitamins primary objective was to test the non-inferiority of the 5-FU CVC compared with the CH-SS CVC in preventing catheter tip colonization (CTC), defined as the growth of 15 CFU on CVC tips prepared by the standard roll-plate method. The sample size was based on the estimation that 395 patients would be required per treatment group in order to detect, with 90% power, a significant difference in the rates of colonization between the two types of catheters at a one-tailed significance level of 5%, as is standard for non-inferiority analyses. Based on supportive evidence from the medical literature (Rijnders et al., 2002; Ramritu et al., 2008), CTC was used in this study as a surrogate end point for catheter-related bloodstream infection (CRBSI). Secondary objectives were to test the non-inferiority of the 5-FU CVC compared with the CH-SS CVC for the prevention of CRBSI, defined as growth of the same species with an identical antib...